imikhiqizo
Ikhwalithi ephezulu ye-L-Glutathione Yehlisiwe i-CAS 70-18-8 ye-Skin Care Glutathione
Imininingwane yomkhiqizo
MF: C10H17N3O6S
MW: 307.32
CAS: 70-18-8
I-1.I-Glutathione iyinhlanganisela ye-tripeptide ehlanganiswe ne-glutamic acid, i-cysteine ne-glycine ngamabhondi e-peptide.Ibaluleke kakhulu i-mercaptan yamangqamuzana aphansi kumaseli ezincelisayo ngaphansi kwengcindezi ye-antioxidant.
I-2.Glutathione (GSH) iyinhlanganisela ye-tripeptide eyakhiwe yi-condensation ye-glutamic acid, i-cysteine ne-glycine ngokusebenzisa izibopho ze-peptide.Igama layo lamakhemikhali lithi γ- Ifomula yesakhiwo ye-l-glutamyl-l-cysteyl-glycine iboniswa kumfanekiso 1chemicalbook.Ngokwefomula yesakhiwo esithombeni, i-GSH ihlukile kwamanye ama-peptide namaprotheni.Kukhona isibopho esikhethekile se-peptide ku-molecule yayo, eyenziwe nge-glutamic acid γ- Carboxyl (- COOH) ne-cysteine α- Peptide bond eyakhiwe ukufingqa kwe-amino - (- NH2).
3.Isisindo samangqamuzana e-glutathione singama-307.33, indawo encibilikayo ingu-189 ~ 193 ℃ (ukubola), i-crystal ayinambala, i-transparent, ikholomu encane, futhi iphuzu le-isoelectric lingu-5.93.Iyancibilika emanzini, i-dilute alcohol, i-ammonia ewuketshezi ne-methyl formamide, kodwa ayincibiliki otshwaleni, i-ether ne-acetone.I-GSH kuphela enomsebenzi wokuphila emzimbeni, futhi i-GSSG ingadlala umsebenzi wayo obalulekile wokuphila ngemva kokuncipha.I-GSH akulula ukuyigcina ngaphansi kokusebenza kwamanzi amaningi, futhi ingagcinwa ngokuzinza isikhathi eside kuphela lapho umsebenzi wamanzi ulawulwa ngaphansi kuka-0.3.Ucwaningo luye lwabonisa ukuthi ku-vitamin ccchemicalbook isixazululo samanzi esine-GSH (ph3.3), ngenxa yokunciphisa okunamandla kwe-vitamin C, i-GSH esixazululweni ngeke ifakwe i-oxidized ku-GSSG, kodwa isivinini sayo sokubola siyasheshisa;I-GSSG kuvithamini C kusisombululo samanzi ngeke iguqulwe ibe yi-GSH, futhi ukugcinwa kwayo kokuqina kuhle kakhulu.Ngaphezu kwalokho, i-GSSG egaywe ngomlomo ingancishiswa ibe yi-GSH engxenyeni engenhla yamathumbu amancane, futhi ingaphezulu lamangqamuzana amancane e-epithelial emathunjini γ- GTP (ebola i-GSH ibe i-glutamic acid ne-Cys Gly) kanye ne-dipeptidase nayo ingadlala indima ebalulekile ye-physiological. imisebenzi.
I-4.Glutathione ikhona kakhulu ezilwaneni nasezitshalweni, futhi okuqukethwe kwayo kumvubelo yokubhaka, igciwane likakolweni nesibindi sesilwane liphezulu kakhulu, lifinyelela ku-100 ~ 1000mg/100g;Futhi inothile ngegazi labantu nelezilwane, njengokuthi 26chemicalbook ~ 34mg/100g egazini lomuntu, 58 ~ 73mg/100g egazini lenkukhu, 10 ~ 15mg/100g egazini lengulube kanye no-14 ~ 22mg/100g egazini lenja.I-GSH iyatholakala futhi emifino eminingi, amazambane kanye nokusanhlamvu.
Isicelo
1.I-glutathione eyehlisiwe iyi-peptide ye-molecule encane, etholakala ngobuningi ezinto eziphilayo, ikakhulukazi kumaseli esibindi.Ingavikela ulwelwesi lwamangqamuzana esibindi, ikhuthaze umsebenzi we-enzyme yesibindi, futhi ihlanganise namakhemikhali amaningi anobuthi ku-chemicalbook ukuze ikhiphe ubuthi.Kunomphumela omuhle ekulimaleni kwesibindi, i-cirrhosis yesibindi nezinye izifo ezibangelwa ubuthi bezidakamizwa, ukuphuza utshwala nezinye izizathu.
I-2.Inomsebenzi we-antioxidation, ukukhipha ama-radicals mahhala, ukuqeda ubuthi, ukuqinisa amasosha omzimba, ukubambezeleka ukuguga, ukulwa nomdlavuza, ukulimala kwe-radicals nokunye.
3.Ama-reagents e-biochemical kanye nama-antidotes asetshenziselwa ikakhulukazi ubuthi bezinsimbi ezisindayo, i-acrylonitrile, i-fluoride, i-carbon monoxide kanye nezinyibilikisi eziphilayo.
I-4.I-Endogenous Antioxidants edlala indima ebalulekile ekunciphiseni izinhlobo ze-oksijini ezisebenzayo ezakhiwe ngesikhathi se-cell metabolism kanye nokuphefumula okungazelelwe.I-Glutathione-S-transferase ikhuthaza ukwakheka kwe-glutathione sulfide nge-xenobiotics, i-leukotrienes namanye ama-molecule anezikhungo ze-electrophilic.I-Glutathione futhi yakha izibopho ze-disulfide nezinsalela ze-cysteine kumaprotheni.Ngalezi zindlela, kungaba nomthelela oyinqaba wokunciphisa ukusebenza kwama-anticancer agents.
