I-Tetracaine hydrochloride

Incazelo emfushane:

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane yomkhiqizo

MF: C15H25ClN2O2
MW: 300.82
CAS: 136-47-0

1.I-Tetracaine hydrochloride iyi-anesthetic yendawo esebenza kahle kakhulu engavimba ukusebenza kwezinzwa ngokuhlehla.Isetshenziselwa izinzwa zokungena, i-nerve block anesthesia, i-epidural anesthesia, njll. uma kuqhathaniswa ne-procaine, umphumela wayo wendawo we-anesthesia ubalulekile, futhi usetshenziswe kabanzi emtholampilo.Ngokutadisha imizila ekhona yokuhlanganisa, kutholakala ukuthi ukuhlanganiswa kwe-p-butylamino benzoic acid ephakathi kuyisinyathelo esibalulekile ekuhlanganisweni kwe-tetracaine hydrochloride, enokushiyeka kwezinto ezingavuthiwe ezingazinzile noma isivuno esincane.Ososayensi bakuthuthukisile lokhu.Ku-1981, bahlongoze ukuhlanganiswa kwe-p-butylamino benzoic acid nge-alkylating p-aminobenzoic acid ne-1-Bromobutane.Kodwa-ke, ngenxa yokwakheka okungenakugwemeka kwemikhiqizo engaphansi kwe-dibutylation kanye nemvelo engazinzile yezinto zokusetshenziswa, lo mzila awufanele ukukhiqizwa kwezimboni.

2.I-Tetracaine hydrochloride isetshenziselwa i-anesthesia yendawo ye-mucosal, i-anesthesia yokuqhuba, i-epidural anesthesia kanye ne-subarachnoid anesthesia;Isetshenziselwa i-ophthalmic surface anesthesia, ayivimbeli imithambo yegazi, ayilimazi i-corneal epithelium, futhi ayikhulisi ukucindezeleka kwe-intraocular.

3. Lesi sidakamizwa singathuthukisa umphumela we-nerve block ye-cisatracurium, futhi umthamo walokhu wokugcina kufanele uncishiswe uma uhlanganisiwe.Uma ihlanganiswa ne-adrenaline, ingaminyanisa imithambo yegazi, inciphise ukugeleza kwegazi, ukumuncwa kancane kwezidakamizwa, futhi andise ubude besikhathi sokusebenza.Kodwa inhlanganisela yalokhu kokubili ayifanele iziguli ezinesifo senhliziyo, umfutho wegazi ophakeme, i-hyperthyroidism, isifo se-vascular peripheral njalonjalo.I-Hyaluronidase ingakhuphula ngempumelelo ukusabalalisa kwalesi sidakamizwa, isheshise ukuqala kwe-anesthesia, inciphise ukuvuvukala kwendawo, futhi ivimbele ukwakheka kwe-hematoma.Kodwa-ke, i-hyaluronidase ingasheshisa ukumuncwa kwalesi sidakamizwa, okuholela ekwandeni kobuthi be-anti chemical Book balesi sidakamizwa.Lesi sidakamizwa siphuma ku-p-aminobenzoic acid (PABA).I-sulfonamides yenza umphumela we-antibacterial ngokuvimbela i-PABA yamagciwane.Uma lesi sidakamizwa sihlanganiswa ne-sulfonamides, umphumela we-antibacterial we-antibacterial uzovinjelwa, ngakho-ke kokubili akufanele kuhlanganiswe.Lo muthi une-acidic futhi akufanele uhlanganiswe nomuthi we-alkaline liquid;Ngisho nezidakamizwa ezine-acidic zingathinta inani lokuhlukanisa lomuthi ngenxa ye-pH ehlukene, okuholela esenzweni esincishisiwe noma ukubambezeleka kwesikhathi sokuqala.Ukulungiswa kwe-iodine kungabangela imvula yalo muthi, ngakho indawo yomjovo yalesi sidakamizwa ayikwazi ukusetshenziswa.

Isicelo

Lo mkhiqizo uyi-ester yokubulala izinzwa yasendaweni esebenza isikhathi eside.Izici zayo zesenzo yilezi: ukungena okuqinile ku-mucosa, kulungele i-anesthesia yendawo, futhi akukho ukusabela okubi okufana ne-vasoconstriction, i-mydriasis, ukulimala kwe-cornea ngemva kokuwa kwamehlo.Isetshenziswa kakhulu ku-ophthalmology.Umthelela wendawo yokubulala izinzwa nobuthi cishe kukhulu ngokuphindwe ka-10 kune-procaine.Ngemuva komjovo, umphumela wokubulala izinzwa we-chemicalbook uvela kancane (cishe imizuzu eyi-10), futhi i-metabolism nayo ihamba kancane ngemva kokumuncwa.Isikhathi sendawo yokubulala izinzwa sifika ku-3ij, h, -j.mayelana.Isetshenziselwa ikakhulukazi izinzwa ezingaphezulu zeso, ikhala nomphimbo mucosa, futhi kuyaqabukela isetshenziselwe conduction izinzwa kanye epidural izinzwa.Ngokuvamile, ayisetshenziselwa i-anesthesia yokungena ngenxa yobuthi bayo obukhulu.

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